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Castle Biosciences, Inc. (CSTL) Stock

Healthcare · Medical - Diagnostics & Research · US
$33.99 -1.25%
Last updated Nov 12, 2026 10:46 UTC

CSTL Key Statistics

Market Cap$1.04B
P/E (TTM)-44.07
P/S (TTM)2.75
P/B (TTM)2.18
Revenue (TTM)$377.13M
EPS (TTM)$-0.77
Dividend Yield—
ROE (TTM)-4.89%
Net Margin-6.10%
Gross Margin77.07%
52W High$44.13
52W Low$17.72
Analyst ViewBuy
Price Target$38.75
Employees1,002
Volume335,269

About Castle Biosciences, Inc.

Castle Biosciences, Inc. functions as a commercial-stage diagnostics firm, with its primary objective being the provision of both diagnostic and prognostic testing services, specifically targeting various dermatological cancers. Their flagship product, DecisionDx-Melanoma, represents an advanced multi-gene expression profile (GEP) assay engineered to assess the probability of metastasis in patients afflicted with invasive cutaneous melanoma. In addition to their leading solution, the company has created several other specialized, proprietary tests. Among these is DecisionDx-UM, a GEP test tailored to forecast the risk of metastasis for individuals with uveal melanoma, a less common malignancy of the eye. Another key offering is DecisionDx-SCC, a distinctive 40-gene expression profile test that utilizes a patient's unique tumor biology to predict their specific risk of squamous cell carcinoma metastasis, particularly for those presenting with recognized risk factors. Moreover, they offer DecisionDx DiffDx-Melanoma and myPath Melanoma, both proprietary GEP tests employed to assist in the accurate diagnosis of ambiguous pigmented lesions. These specialized testing services are provided by Castle Biosciences to patients predominantly through their healthcare providers. The organization commenced operations in 2007 and maintains its corporate headquarters in Friendswood, Texas.

CEO: Derek J. Maetzold. Company website

CSTL — Frequently Asked Questions

What is the CSTL stock price today?

Castle Biosciences, Inc. (CSTL) trades at $33.99, down 1.25% on the day, as of Nov 12, 2026 10:46 UTC.

What is Castle Biosciences, Inc.'s market cap?

Castle Biosciences, Inc. has a market capitalisation of $1.04B, calculated from the live CSTL share price and shares outstanding.

What is the P/E ratio of CSTL?

CSTL has no meaningful price-to-earnings ratio: Castle Biosciences, Inc. lost $0.77 per share over the last twelve months, and a P/E is only defined on positive earnings.

How much revenue does Castle Biosciences, Inc. make?

Castle Biosciences, Inc. generated revenue of $377.13M over the trailing twelve months, which puts the stock at 2.75 times sales.

What is the 52-week range for CSTL?

CSTL has traded between $17.72 and $44.13 over the past 52 weeks, and the last price is 23.0% below that high.

Is Castle Biosciences, Inc. profitable?

No. Castle Biosciences, Inc. is loss-making, with a net margin of -6.10% over the trailing twelve months.

What is the analyst price target for CSTL?

Wall Street analysts rate CSTL Buy, with an average price target of $38.75, 14.0% above the current price.

What sector is Castle Biosciences, Inc. in?

Castle Biosciences, Inc. is classified under the Healthcare sector and the Medical - Diagnostics & Research industry, and is domiciled in US.

Who is the CEO of Castle Biosciences, Inc.?

Derek J. Maetzold is the chief executive of Castle Biosciences, Inc., which employs 1,002 people.

Where can I track CSTL in real time?

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ETFs holding CSTL

IBB iShares Biotechnology ETF 0.07% IWM iShares Russell 2000 ETF 0.04% SCHA Schwab U.S. Small-Cap ETF 0.03% SCHB Schwab U.S. Broad Market ETF 0.00% VTI Vanguard Morningstar Total Stock Market ETF 0.00%

Largest institutional holders of CSTL

BlackRock, Inc. BLK 3,291,963 shares
RTW INVESTMENTS, LP 2,778,335 shares
VANGUARD CAPITAL MANAGEMENT LLC 1,226,497 shares
ACADIAN ASSET MANAGEMENT LLC 881,863 shares
Allianz Asset Management GmbH 879,258 shares
VANGUARD PORTFOLIO MANAGEMENT LLC 840,785 shares
SUMMIT PARTNERS PUBLIC ASSET MANAGEMENT, LLC 824,872 shares
STATE STREET CORP STT 822,079 shares
GEODE CAPITAL MANAGEMENT, LLC 793,904 shares