Founded in 1989 and headquartered in Carlsbad, California, Ionis Pharmaceuticals, Inc. is a biopharmaceutical company specializing in the discovery and development of RNA-targeted therapies within the United States. Its commercial portfolio includes three key medications: SPINRAZA, prescribed for spinal muscular atrophy (SMA) in both children and adults; TEGSEDI, an injectable treatment targeting polyneuropathy associated with hereditary transthyretin-mediated amyloidosis in adult patients; and WAYLIVRA, which addresses familial chylomicronemia syndrome and familial partial lipodystrophy. Ionis also maintains a robust pipeline, with several drug candidates currently in Phase 3 clinical trials. These include Eplontersen, a monthly self-administered subcutaneous injection designed for all forms of TTR amyloidosis; Olezarsen, intended for individuals with severe hypertriglyceridemia (SHTG); Donidalorsen, for patients suffering from hereditary angioedema; ION363, aimed at amyotrophic lateral sclerosis (ALS); Pelacarsen, developed for those with established cardiovascular disease and elevated lipoprotein(a); and Tofersen, which works by inhibiting the production of superoxide dismutase 1. Beyond these late-stage assets, the company is actively researching treatments for metabolic, infectious, renal, and ophthalmic diseases, as well as various types of cancer. The firm engages in significant collaborations, notably a strategic partnership with Biogen Inc. Additionally, it holds licensing and collaboration agreements with AstraZeneca, Bayer AG, GlaxoSmithKline plc, Novartis AG, Roche, Janssen Biotech, Inc., and Flamingo Therapeutics, Inc.
CEO: Brett Monia. Company website
Ionis Pharmaceuticals, Inc. (IONS) trades at $44.44, down 4.94% on the day, as of Sep 20, 2026 14:59 UTC.
Ionis Pharmaceuticals, Inc. has a market capitalisation of $7.39B, calculated from the live IONS share price and shares outstanding.
IONS has no meaningful price-to-earnings ratio: Ionis Pharmaceuticals, Inc. lost $3.46 per share over the last twelve months, and a P/E is only defined on positive earnings.
Ionis Pharmaceuticals, Inc. generated revenue of $873.76M over the trailing twelve months, which puts the stock at 8.45 times sales.
IONS has traded between $44.27 and $86.74 over the past 52 weeks, and the last price is 48.8% below that high.
No. Ionis Pharmaceuticals, Inc. is loss-making, with a net margin of -64.64% over the trailing twelve months.
Wall Street analysts rate IONS Buy, with an average price target of $87.00, 95.8% above the current price.
Ionis Pharmaceuticals, Inc. is classified under the Healthcare sector and the Biotechnology industry, and is domiciled in US.
Brett Monia is the chief executive of Ionis Pharmaceuticals, Inc., which employs 1,480 people.
QFI Terminal shows IONS with live charts, full financials, the options chain with gamma exposure, institutional ownership and analyst ratings on one screen. The free plan has no time limit and asks for no card.
Interactive charts, full financials, options chain, gamma exposure, ownership and analyst ratings, all in one institutional-grade terminal.
Open IONS in Terminal See plans