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Vertex Pharmaceuticals Incorporated (VRTX) Stock

Healthcare · Biotechnology · US
$547.03 -0.16%
Last updated Nov 12, 2026 09:20 UTC

VRTX Key Statistics

Market Cap$138.65B
P/E (TTM)35.20
P/S (TTM)10.71
P/B (TTM)6.63
Revenue (TTM)$12.95B
EPS (TTM)$15.54
Dividend Yield—
ROE (TTM)20.08%
Net Margin30.70%
Gross Margin85.53%
52W High$568.67
52W Low$406.67
Analyst ViewBuy
Price Target$580.20
Employees6,400
Volume1,027,934

About Vertex Pharmaceuticals Incorporated

Vertex Pharmaceuticals Incorporated is a leading biotechnology firm primarily focused on the discovery, advancement, and marketing of innovative treatments, particularly for cystic fibrosis (CF). The company offers a range of approved medications for CF patients, including SYMDEKO/SYMKEVI, ORKAMBI, and KALYDECO, which target specific mutations within the cystic fibrosis transmembrane conductance regulator gene. Additionally, they provide TRIKAFTA for individuals with CF aged six years and older who possess at least one F508del mutation. Beyond its established CF therapies, Vertex maintains a robust and diverse clinical pipeline. This includes VX-864, currently in Phase 2 for alpha-1 antitrypsin (AAT) deficiency; VX-147, also in Phase 2, addressing APOL1-mediated focal segmental glomerulosclerosis (FSGS) and other serious kidney conditions; VX-880, a potential treatment for Type 1 Diabetes undergoing Phase 1/2 trials; VX-548, a NaV1.8 inhibitor in Phase 2 for various forms of acute, neuropathic, and musculoskeletal pain; and CTX001, which is in Phase 3 development for severe sickle cell disease (SCD) and transfusion-dependent beta-thalassemia (TDT). The company distributes its pharmaceutical products through specialty pharmacies and distributors across the United States, while international sales are facilitated via a network of specialty distributors, retail chains, hospitals, and clinics. Vertex also engages in numerous strategic collaborations with partners such as Affinia Therapeutics, Arbor Biotechnologies, CRISPR Therapeutics, Kymera Therapeutics, Mammoth Biosciences, Moderna, Obsidian Therapeutics, Skyhawk Therapeutics, Ribometrix, Genomics plc, Merck KGaA, and X-Chem. Established in 1989, Vertex Pharmaceuticals is headquartered in Boston, Massachusetts.

CEO: Reshma Kewalramani. Company website

VRTX — Frequently Asked Questions

What is the VRTX stock price today?

Vertex Pharmaceuticals Incorporated (VRTX) trades at $547.03, down 0.16% on the day, as of Nov 12, 2026 09:20 UTC.

What is Vertex Pharmaceuticals Incorporated's market cap?

Vertex Pharmaceuticals Incorporated has a market capitalisation of $138.65B, calculated from the live VRTX share price and shares outstanding.

What is the P/E ratio of VRTX?

VRTX trades at a trailing P/E of 35.20, from earnings per share of $15.54 over the last twelve months.

How much revenue does Vertex Pharmaceuticals Incorporated make?

Vertex Pharmaceuticals Incorporated generated revenue of $12.95B over the trailing twelve months, which puts the stock at 10.71 times sales.

What is the 52-week range for VRTX?

VRTX has traded between $406.67 and $568.67 over the past 52 weeks, and the last price is 3.8% below that high.

Is Vertex Pharmaceuticals Incorporated profitable?

Yes. Vertex Pharmaceuticals Incorporated keeps 30.70% of revenue as net income over the trailing twelve months.

What is the analyst price target for VRTX?

Wall Street analysts rate VRTX Buy, with an average price target of $580.20, 6.1% above the current price.

What sector is Vertex Pharmaceuticals Incorporated in?

Vertex Pharmaceuticals Incorporated is classified under the Healthcare sector and the Biotechnology industry, and is domiciled in US.

Who is the CEO of Vertex Pharmaceuticals Incorporated?

Reshma Kewalramani is the chief executive of Vertex Pharmaceuticals Incorporated, which employs 6,400 people.

Where can I track VRTX in real time?

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ETFs holding VRTX

IBB iShares Biotechnology ETF 7.90% XLV State Street Health Care Select Sector SPDR ETF 2.04% XBI State Street SPDR S&P Biotech ETF 1.53% USMV iShares MSCI USA Min Vol Factor ETF 1.42% QQQ Invesco QQQ Trust, Series 1 0.66% QQQM Invesco NASDAQ 100 ETF 0.66% MGK Vanguard Morningstar Mega Cap Growth ETF 0.61% QUAL iShares MSCI USA Quality Factor ETF 0.48% SCHG Schwab U.S. Large-Cap Growth ETF 0.40% TQQQ ProShares UltraPro QQQ 0.38% VUG Vanguard Morningstar Growth ETF 0.37% IWD iShares Russell 1000 Value ETF 0.36% IVV iShares Core S&P 500 ETF 0.22% SPY State Street SPDR S&P 500 ETF 0.21% SCHX Schwab U.S. Large-Cap ETF 0.21% RSP Invesco S&P 500 Equal Weight ETF 0.21% VOO Vanguard S&P 500 ETF 0.20% IWB iShares Russell 1000 ETF 0.20% SCHB Schwab U.S. Broad Market ETF 0.19% FB ProShares S&P 500 Dynamic Buffer ETF 0.19% VTI Vanguard Morningstar Total Stock Market ETF 0.18% ACWI iShares MSCI ACWI ETF 0.14% UPRO ProShares - UltraPro S&P500 0.12% FNDX Schwab Fundamental U.S. Large Company ETF 0.12% VT Vanguard Total World Stock ETF 0.11% SPXL Direxion Daily S&P 500 Bull 3X Shares 0.05%

Largest institutional holders of VRTX

Capital World Investors 26,115,014 shares
BlackRock, Inc. BLK 24,109,373 shares
Capital Research Global Investors 19,490,637 shares
VANGUARD CAPITAL MANAGEMENT LLC 16,580,713 shares
STATE STREET CORP STT 11,871,459 shares
Invesco Ltd. IVZ 8,043,052 shares
JPMORGAN CHASE & CO JPM 6,517,600 shares
GEODE CAPITAL MANAGEMENT, LLC 6,081,969 shares
VANGUARD PORTFOLIO MANAGEMENT LLC 4,878,987 shares
Capital International Investors 4,695,144 shares

VRTX insiders on other boards

V Visa Inc. Carney Lloyd MET MetLife, Inc. Mckenzie Diana WST West Pharmaceutical Services, Inc. Lagarde Michel DNLI Denali Therapeutics Inc. Thornberry Nancy MDGL Madrigal Pharmaceuticals, Inc. Brennan Daniel J. TJX The TJX Companies, Inc. Wagner Charles F Jr ALNY Alnylam Pharmaceuticals, Inc. Arbuckle Stuart A INCY Incyte Corporation Upadhyay Suketu ZBH Zimmer Biomet Holdings, Inc. Upadhyay Suketu TMO Thermo Fisher Scientific Inc. Lagarde Michel WAT Waters Corporation Brennan Daniel J.