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Denali Therapeutics Inc. (DNLI) Stock

Healthcare · Biotechnology · US
$19.73 -0.60%
Last updated Nov 12, 2026 09:30 UTC

DNLI Key Statistics

Market Cap$3.15B
P/E (TTM)-11.39
P/S (TTM)147.50
P/B (TTM)4.01
Revenue (TTM)$21.38M
EPS (TTM)$-1.73
Dividend Yield—
ROE (TTM)-33.98%
Net Margin-1,470.50%
Gross Margin71.96%
52W High$27.30
52W Low$13.75
Analyst ViewBuy
Price Target$33.67
Employees503
Volume873,556

About Denali Therapeutics Inc.

Denali Therapeutics Inc. is a biopharmaceutical firm, founded in 2013 and based in South San Francisco, California, which focuses on identifying and advancing treatments for neurodegenerative conditions within the United States. The company, initially known as SPR Pharma Inc. until its renaming in March 2015, possesses a robust development pipeline. This includes BIIB122/DNL151, a small molecule inhibitor targeting leucine-rich repeat kinase 2 (LRRK2), currently in Phase 1 and Phase 1b clinical trials for Parkinson's disease. Another candidate, DNL310, is progressing through Phase 1/2 clinical studies for Hunter syndrome. For amyotrophic lateral sclerosis (ALS), DNL343 is in Phase 1 trials, while AR443820/DNL788 has successfully concluded its Phase 1 clinical trial for ALS, multiple sclerosis (MS), and Alzheimer's disease. Furthermore, SAR443122/DNL758 is undergoing Phase 2 clinical trials for cutaneous lupus erythematosus. Denali Therapeutics is engaged in extensive collaborative efforts with a range of partners, including Takeda Pharmaceutical Company, Genentech, Inc., Sanofi, F-star Gamma Limited, F-star Biotechnologische Forschungs-Und Entwicklungsges M.B.H, F-star Biotechnology Limited, SIRION Biotech GmbH, Genzyme Corporation, Harvard University, the Michael J. Fox Foundation, and Centogene. It also maintains a research and option agreement with Secarna Pharmaceuticals GmbH & Co. KG to co-develop antisense therapies specifically for neurodegenerative diseases.

CEO: Ryan J. Watts. Company website

DNLI — Frequently Asked Questions

What is the DNLI stock price today?

Denali Therapeutics Inc. (DNLI) trades at $19.73, down 0.60% on the day, as of Nov 12, 2026 09:30 UTC.

What is Denali Therapeutics Inc.'s market cap?

Denali Therapeutics Inc. has a market capitalisation of $3.15B, calculated from the live DNLI share price and shares outstanding.

What is the P/E ratio of DNLI?

DNLI has no meaningful price-to-earnings ratio: Denali Therapeutics Inc. lost $1.73 per share over the last twelve months, and a P/E is only defined on positive earnings.

How much revenue does Denali Therapeutics Inc. make?

Denali Therapeutics Inc. generated revenue of $21.38M over the trailing twelve months, which puts the stock at 147.50 times sales.

What is the 52-week range for DNLI?

DNLI has traded between $13.75 and $27.30 over the past 52 weeks, and the last price is 27.7% below that high.

Is Denali Therapeutics Inc. profitable?

No. Denali Therapeutics Inc. is loss-making, with a net margin of -1,470.50% over the trailing twelve months.

What is the analyst price target for DNLI?

Wall Street analysts rate DNLI Buy, with an average price target of $33.67, 70.7% above the current price.

What sector is Denali Therapeutics Inc. in?

Denali Therapeutics Inc. is classified under the Healthcare sector and the Biotechnology industry, and is domiciled in US.

Who is the CEO of Denali Therapeutics Inc.?

Ryan J. Watts is the chief executive of Denali Therapeutics Inc., which employs 503 people.

Where can I track DNLI in real time?

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ETFs holding DNLI

XBI State Street SPDR S&P Biotech ETF 0.60% IBB iShares Biotechnology ETF 0.21% IWM iShares Russell 2000 ETF 0.10% SCHA Schwab U.S. Small-Cap ETF 0.08% SCHB Schwab U.S. Broad Market ETF 0.00% VTI Vanguard Morningstar Total Stock Market ETF 0.00% VT Vanguard Total World Stock ETF 0.00%

Largest institutional holders of DNLI

T. Rowe Price Investment Management, Inc. 16,178,963 shares
BlackRock, Inc. BLK 14,026,413 shares
BAILLIE GIFFORD & CO 11,119,945 shares
STATE STREET CORP STT 7,049,304 shares
Temasek Holdings (Private) Ltd 7,012,974 shares
VANGUARD PORTFOLIO MANAGEMENT LLC 6,477,057 shares
VANGUARD CAPITAL MANAGEMENT LLC 6,275,729 shares
FMR LLC 4,533,121 shares
GOLDMAN SACHS GROUP INC GS 4,155,895 shares
GEODE CAPITAL MANAGEMENT, LLC 4,038,820 shares

DNLI insiders on other boards

MDGL Madrigal Pharmaceuticals, Inc. Baker Bros. Advisors Lp INCY Incyte Corporation Baker Bros. Advisors Lp GH Guardant Health, Inc. Krognes Steve E. ONC BeOne Medicines AG Baker Bros. Advisors Lp JAZZ Jazz Pharmaceuticals plc Cook Jennifer E. REPL Replimune Group, Inc. Baker Bros. Advisors Lp BBIO BridgeBio Pharma, Inc. Cook Jennifer E. RIVN Rivian Automotive, Inc. Flatley Jay T RPRX Royalty Pharma plc Ho Carole VRTX Vertex Pharmaceuticals Incorporated Thornberry Nancy REGN Regeneron Pharmaceuticals, Inc. Schenkein David P BEAM Beam Therapeutics Inc. Ho Carole